Step 3 is taking the isolated PRP created from the previous step and injecting it into strategic areas. Using a very small needle, you will be injected with your own growth factors in a particular way. These growth factors then activate multi-potent stem cells already in the skin, tricking them into “thinking” there’s been an injury and then generate newer, and younger tissue.
Providers of the Vampire Facelift (R) procedure take into account the mathematics of beauty as defined by much research (starting with the notebooks of Lonardo da Vinci) to avoid at all costs creating an unnatural shape.  These ideas about the HA fillers are not commonly known even among the best of cosmetic surgeons and constitute part of the intellectual property protected by the trademarked name (Vampire Facelift®).
The deal is this: Blood is drawn, usually from the client’s arm, then placed in a centrifuge in order to separate the plasma and the platelets from red blood cells. The resulting liquid is called platelet-rich plasma, or PRP. The plasma contains protein and other nutrients that are supposed to help stimulate skin cell growth and collagen. Then that material is either applied topically or injected into the face using microneedling techniques, which essentially involves puncturing the skin many times with super-tiny needles. The theory is that the holes help the growth factors and other nutrients get into deeper layers of the skin.
"It's one of the most popular treatments at my practice," says Gary Goldenberg, M.D., assistant clinical professor of dermatology at the Icahn School of Medicine at Mount Sinai Hospital. "We use it to treat acne, acne scarring, melasma, surgical scars, and fine wrinkles and lines." (PRP can also be used on your scalp to treat hair loss because it can stimulate hair growth.)
Tell your doctor if you have received any other botulinum toxin product in the last 4 months; have received injections of botulinum toxin such as Myobloc®, Dysport®, or Xeomin® in the past (tell your doctor exactly which product you received); have recently received an antibiotic by injection; take muscle relaxants; take an allergy or cold medicine; take a sleep medicine; take aspirin-like products or blood thinners.
The Vampire Facelift® is actually not a surgical facelift at all, but rather a type of skin treatment using the body’s own natural healing and growth factors that are derived from your own blood (hence the name The Vampire Facelift®), combined with a hyaluronic acid dermal filler. The procedure is a near painless series of injections into strategic areas of the face to reduce wrinkles, add youthful volume, and improve the quality of your skin.
“Selphyl is not a filler – it’s a truly regenerative treatment that involves harvesting the body’s own wound healing and regenerative growth factors to improve skin texture, as well as age-related changes like fine lines and laxity,” says Dr. Jennifer Pearlman, staff physician at Mount Sinai Hospital, menopause clinic and owner of PearlMD Rejuvenation, where the treatment is also offered.
The basic PRP treatment has been used for almost 20 years to accelerate the healing of wounds and burnt skin, and help athletes - including, reportedly, tennis ace Rafael Nadal - recover from injury. But it was when Dr Charles Runels from Alabama trademarked the name "Vampire Facelift" in 2010, during the craze for the Vampire Diaries and Twilight Saga, that the procedure became attractive for A-listers.
After an initial consultation appointment, a second visit is required for the actual procedure: Blood is drawn (just like a regular blood test) and then spun in a centrifugation system to separate the platelet-rich plasma (PRP) from the other blood elements. This is then injected with tiny needles into the superficial layers of the skin (called mesotherapy).

One of the reasons the PRP Facial is so popular is because it works miracles on acne scars and stretch marks. It also increases skin’s elasticity, fights wrinkles by stimulating collagen, and has no side effects. How does it work? When Platelet-rich plasma is applied before and after microneedling it releases at least eight essential growth factors and signaling proteins into the skin. These work to repair tissue and blood vessels, promote the growth of new tissue, and boost healthy cell production.
Once the treatment is complete, Chang applies a soothing cream that contains stem cells and then sunscreen to the patient’s face. She compares the treatment to a chemical peel or a laser in terms of inducing local trauma to boost collagen. To further accelerate the healing process for patients, Chang often uses an LED light. For about 20 minutes post-procedure, patients remain on the treatment table under a tri-paneled lamp. Infrared light is known to accelerate skin recovery and red light is known to reduce inflammation.
Typically, the process includes the initial blood draw, then running the blood through a centrifuge to isolate the platelets. You'll then receive microneedling or microdermabrasion just before your PRPs are slathered across your face. This can be accompanied with or without radio frequency, too. "It sounds gory and mysterious, but in fact, it is central to our evolving understanding of the physiology of the skin and advanced techniques with which to improve the quality of the skin," says Shamban.
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